William C Dougall Selected Research

Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)

1/2008	RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes.
7/2007	Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection.
11/2005	The effects of RANK blockade and osteoclast depletion in a model of pure osteoblastic prostate cancer metastasis in bone.
11/2002	A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function.
2/2002	In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis.

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William C Dougall Research Topics

Disease

43	Neoplasms (Cancer) 10/2020 - 11/2005
19	Neoplasm Metastasis (Metastasis) 01/2019 - 11/2005
14	Bone Resorption 02/2014 - 02/2002
11	Breast Neoplasms (Breast Cancer) 07/2017 - 04/2010
9	Osteolysis 09/2015 - 02/2002
7	Prostatic Neoplasms (Prostate Cancer) 08/2012 - 11/2005
5	Melanoma (Melanoma, Malignant) 01/2020 - 01/2018
5	Carcinogenesis 01/2016 - 11/2010
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2019 - 03/2014
3	Adenocarcinoma 10/2016 - 04/2010
2	Multiple Myeloma 10/2018 - 02/2008
2	Lung Neoplasms (Lung Cancer) 01/2018 - 10/2006
2	Bone Diseases (Bone Disease) 02/2009 - 12/2007
1	Chronic Disease (Chronic Diseases) 10/2020
1	Inflammation (Inflammations) 10/2020
1	Renal Cell Carcinoma (Grawitz Tumor) 12/2019
1	Poliomyelitis (Polio) 01/2018
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Osteosarcoma (Osteogenic Sarcoma) 09/2015
1	Salivary Gland Neoplasms (Salivary Gland Cancer) 01/2015
1	Spontaneous Fractures (Pathological Fracture) 01/2014
1	Spinal Cord Compression 01/2014
1	Postmenopausal Osteoporosis 08/2012
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2010
1	Hypercalcemia (Milk Alkali Syndrome) 07/2007
1	Infections 07/2007
1	Human Influenza (Influenza) 07/2007
1	Hyperalgesia 01/2006
1	Pain (Aches) 01/2006
1	Bone Neoplasms (Bone Cancer) 01/2006

Drug/Important Bio-Agent (IBA)

16	RANK LigandIBA 11/2018 - 11/2002
13	LigandsIBA 10/2020 - 07/2003
10	Immune Checkpoint InhibitorsIBA 10/2020 - 11/2016
10	Denosumab FDA Link 12/2019 - 02/2009
8	Proteins (Proteins, Gene)FDA Link 10/2020 - 11/2005
8	Hormones (Hormone)IBA 10/2016 - 07/2008
7	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2014 - 01/2008
7	Rank-FcIBA 03/2011 - 02/2002
6	Progesterone FDA LinkGeneric 01/2016 - 11/2010
6	OsteoprotegerinIBA 03/2014 - 01/2006
5	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 01/2008 - 02/2002
4	Messenger RNA (mRNA)IBA 01/2019 - 01/2008
4	CalciumIBA 03/2014 - 07/2008
3	Phenobarbital (Luminal)FDA Link 01/2016 - 09/2013
3	Monoclonal AntibodiesIBA 09/2015 - 02/2009
2	AntibodiesIBA 01/2019 - 01/2018
2	CytokinesIBA 10/2017 - 01/2015
2	Immunoglobulin G (IgG)IBA 10/2017 - 07/2007
2	Biomarkers (Surrogate Marker)IBA 08/2014 - 12/2007
2	Docetaxel (Taxotere)FDA Link 03/2014 - 07/2008
2	Estrogen ReceptorsIBA 10/2012 - 06/2012
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 03/2011 - 01/2009
2	Caspase 3 (Caspase-3)IBA 07/2008 - 01/2008
2	Tartrate-Resistant Acid PhosphataseIBA 01/2006 - 02/2002
1	Tyrosine (L-Tyrosine)FDA Link 10/2020
1	src-Family KinasesIBA 10/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020
1	AntigensIBA 01/2019
1	Immunoglobulins (Immunoglobulin)IBA 10/2018
1	Programmed Cell Death 1 ReceptorIBA 10/2018
1	Virus ReceptorsIBA 01/2018
1	pembrolizumabIBA 01/2018
1	IpilimumabIBA 01/2018
1	NectinsIBA 01/2018
1	NivolumabIBA 01/2018
1	Glycoproteins (Glycoprotein)IBA 01/2018
1	Fc Receptors (Fc Receptor)IBA 10/2017
1	Neutralizing AntibodiesIBA 10/2017
1	Transcription Factors (Transcription Factor)IBA 10/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016
1	ElementsIBA 09/2015
1	Progesterone Receptors (Progesterone Receptor)IBA 02/2015
1	Matrix Metalloproteinases (MMPs)IBA 02/2014
1	Zoledronic Acid (Zometa)FDA Link 02/2014
1	tiboloneIBA 01/2013
1	Estrogens (Estrogen)FDA Link 01/2013
1	Tamoxifen FDA LinkGeneric 10/2012
1	CarcinogensIBA 11/2010
1	Cyclin D1IBA 11/2010
1	Progestins (Progestagens)IBA 11/2010
1	ErbB Receptors (EGF Receptor)IBA 06/2010
1	Panitumumab (Vectibix)FDA Link 06/2010
1	human TNFSF10 proteinIBA 04/2010
1	TNF-Related Apoptosis-Inducing LigandIBA 04/2010
1	FluoridesIBA 01/2009
1	Cholecalciferol (Vitamin D3)FDA Link 07/2007
1	enhanced green fluorescent proteinIBA 06/2007
1	Glial Fibrillary Acidic ProteinIBA 01/2006
1	NF-kappa B (NF-kB)IBA 01/2006
1	Pharmaceutical PreparationsIBA 07/2003

Therapy/Procedure

16	Therapeutics 10/2020 - 11/2005
8	Immunotherapy 10/2020 - 11/2016
3	Drug Therapy (Chemotherapy) 10/2016 - 07/2008
1	Prophylactic Mastectomy 01/2016
1	Molecular Targeted Therapy 01/2015
1	Radiotherapy 01/2014
1	Orthopedic Procedures 01/2014
1	Biological Therapy 03/2011
1	Injections 01/2006